Medial tibial stress syndrome is something that has always bugged me because I do not know exactly what it is. There are many competing theories that are underpinned by some good research as to what the exact pathophysiology of the condition is. Some of the theories are not consistent with each other. One recent idea that has caught my attention is that medial tibial stress syndrome is bone stress reaction due to increased bending moments in the tibia. Some of the rationale behind that does make sense to me. There is some discussion on this at Podiatry Arena (see: Medial Tibial Stress Syndrome)
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